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. Author manuscript; available in PMC: 2018 Jul 25.
Published in final edited form as: Chem Res Toxicol. 2018 Feb 28;31(3):168–175. doi: 10.1021/acs.chemrestox.7b00264

Table 4.

Geometric means of NNAL glucuronides by UGT2B10 genetic score, Study 2

Glucuronides as percent of total NNAL
UGT2B10 genetic score TNE (nmol/ml) Total NNAL (pmol/ml) both glucuronides N-gluc O-gluc Cotinine glucuronidationb
0
(n=57)		 51.3
(42.8–61.5)		 0.98
(0.81–1.18)		 67.0
(63.9–70.1)		 22.6
(19.7–25.4)		 44.4
(40.6–48.2)		 1.19
(0.87–1.61)
1
(n=35)		 55.5
(44.3–69.4)		 0.91
(0.72–1.15)		 66.2
(62.3–70.1)		 17.7
(14.2–21.3)		 48.5
(43.8– 3.1)		 0.53
(0.36–0.77)
2
(n=11)		 49.4
(32.5–74.9)		 0.86
(0.55–1.34)		 63.0
(55.8–70.3)		 11.4
(4.8–17.9)		 51.7
(43.0–60.4)		 0.011
(0.006–0.023)
p-value 0.81 0.85 0.63 0.01 0.27 <0.0001

Values are means (95% CI), cotinine glucuronidation is the ratio of cotinine glucuronide to cotinine

The genetic score is based on carriers of the T or C variant for rs61750900 and rs116294140, respectively; score=0, rs61750900 GG and rs116294140 AA; score=1 rs61750900 GT or rs116294140 CA; and score=2 rs61750900 TT or rs116294140 CC, or both rs61750900 GT and rs116294140 CA.

Models adjusted for race/ethnicity and TNE.