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Pharmacokinetic parameters of ibuprofen in brain homogenate (hydrolysis, n = 3).
| Parameters | Ibuprofen | Ibu from Glu-Ibu | Ibu from Vc-Ibu | Ibu from Glu-Vc-Ibu |
|---|---|---|---|---|
| AUC(0–t) (µg/g min) | 2782.42 ± 176.55 | 5859.63 ± 337.28 | 6629.24 ± 467.29 | 7308.11 ± 447.86 |
| MRT (min) | 190.28 ± 15.11 | 164.08 ± 20.52 | 158.37 ± 9.33 | 156.77 ± 13.09 |
| Tmax (min) | 15 | 45 | 45 | 50 |
| Cmax (µg/g) | 11.54 ± 1.49 | 47.69 ± 5.77 | 48.54 ± 6.34 | 60.43 ± 2.37 |
| RE | – | 2.10 | 2.38 | 2.63 |
| CE | – | 4.13 | 4.20 | 5.24 |
