Table 3.
Serum hormone levels in Akt1+/+, Akt1+/−, and Akt1−/− mice at PND50.a
| Hormone | Akt1 +/+ b , c | Akt1 +/− c | Akt1 −/− b , c |
|---|---|---|---|
| FSH (ng/ml) | 8.0 ± 1.6 (N = 6) | 7.32 ± 1.3 (N = 6) | 4.8 ± 1.1 (N = 8) |
| Estradiol (pg/ml) | 7.0 ± 3.2 (N = 33) | ND | 12.2 ± 3.0* N = 15 |
| Progesterone (ng/ml) | 3.0 ± 0.8 (N = 12) | ND | 1.1 ± 0.1* (N = 18) |
| LH (ng/ml) | 0.25 ± 0.04 (N = 11) | 0.38 ± 0.15 (N = 6) | 0.91 ± 0.3* (N = 8) |
| Inhibin A (pg/ml) | 99.8 ± 21.8 (N = 4) | 105.9 ± 27.0 (N = 6) | 114.0 ± 19.6 (N = 8) |
| Inhibin B (pg/ml) | 57.4 ± 16.6 (N = 8) | 50.5 ± 9.8 (N = 9) | 33.5 ± 11.0 (N = 8) |
a
Values represent the mean ± SEM; ND, not determined.
b
For the statistical analyses of two genotypes (Akt1+/+ versus Akt1−/−), a Student t-test was used (P < 0.05).
c
For the statistical analyses of all three genotypes, one-way ANOVA was utilized (P < 0.05).
*
Significant differences in a specific serum hormone observed between Akt1+/+ and Akt1−/− animals.