Figure 7.

(+)-SW209415 does not effect in vivo growth of human hematopoietic cancer cells. Irradiated (2.5Gy) 8-week old male NSG mice were transplanted with 5*10⁶ human acute myeloid leukemia (AML) (A) or multiple myeloma (MM) cells (B). Two weeks after transplant mice began intraperitoneal treatment with either vehicle or 2.5 mg/kg (+)-SW209415 twice daily for 21 days. Upon signs of impending animal death (hunching, limited mobility) mice were sacrificed and the frequency of human CD45⁺ cells (for AML) or human CD38⁺ cells (for MM) in mouse marrow was measured via flow cytometry (4 mice/arm). Graphs show means and Standard Error of Mean for animal weights and for human cancer cell numbers in the mouse bone marrow.