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Generation of functional peptides interacting specifically with the third extracellular loop of AE2 protein. (A) Alignment of the third extracellular loop of murine and human AE2 and linear p17AE2, p19AE2, p20AE2 and truncated peptides. (B) p17AE2, p19AE2 and p20AE2 increased proliferation of effector T cells co-cultured with Treg cells in vitro. (C) Sensogram of surface plasmon resonance showing p17AE2 binding to AE2 in a dose dependent manner. ***, P<0.001.
