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letter
. 2018 Jun;103(6):e230–e233. doi: 10.3324/haematol.2017.169516

Figure 3.

Figure 3.

Hematopoietic stem cells (HSCs) primed in vitro with bone marrow (BM) memory CD8+ T-cell supernatant (SN) have long-term, multi-lineage repopulation capacity. (A) Contribution of HSCs primed with control medium or SN derived from BM memory CD8+ T cells to the total circulating white blood cells (WBC) (n=4 mice). (B) Contributions of HSCs primed with CD8+ OT-I TREST SN to the total circulating WBC after primary transplant. (C) Relative contribution to lineage output of HSCs primed with CD8+ OT-I TREST SN 25 weeks after primary transplant (n=5 mice). (D) Contributions of HSCs originally primed (primary donors #1, #3, #5) with CD8+ OT-I TREST SN to the total circulating WBC after secondary transplant. (E) Relative contribution to lineage output of HSCs originally primed with CD8+ OT-I TREST SN 16 weeks after secondary transplant (n=10 mice). Graphs show results of 3 independent experiments.