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. 2018 Mar 22;103(6):939–948. doi: 10.3324/haematol.2017.181354

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Figure 4. — JQ1 treatment increases hematopoietic repopulation after hematopoietic stem cell (HSC) transplantation. Limiting dilution competitive repopulation transplantations were performed by transplanting bone marrow (BM) from CD45.1⁺ JQ1- or control-treated mice together with supporter BM from CD45.2⁺ mice into lethally irradiated CD45.2⁺ recipients. (A and B) Analysis of chimerism after competitive repopulation (n=12; *P<0.05). (C) Extreme limiting dilution analysis (ELDA) for determining the frequency of HSC in transplants (n=8–12; *P<0.05). (D and E) Monitoring of chimerism (D) and survival (E) after retransplantation of the BM of primary recipients into the second generation of mice and over the course of 12 months.