Figure 5.

Altered Hemodynamic Response to DOB 3 Months PMI

Invasive hemodynamics were performed at baseline ± DOB and 3 months PMI ± DOB. (A) Representative pressure-volume loops in the presence and absence of DOB at baseline and 3 months after MI. (B) EDPVR was not altered at either time point ± DOB. (C) ESPVR was significantly altered (specifically the Ees) at baseline ± DOB, but not at 3 months PMI. (D) PRSW was increased at both time points. (E) LVVPed10 was not significantly reduced in the presences of DOB at 3 months PMI. (F) The LVVPes80 was significantly reduced at baseline ± DOB, but not 3 months PMI ± DOB. (G) EF was increased significantly by DOB at 3 months PMI, but only due to modest reduction in ESV. (H) The Ees, 1 of 2 determinants of the ESPVR, was significantly increased at baseline + DOB, but not at 3 months PMI. (I) The volume intercept, second determinant of the ESPVR, was not significantly changed at 3 months PMI ± DOB. Open bars = baseline (B), and gray bars = dobutamine (+), red bars = 3Mo PMI. *p ≤ 0.05, **p ≤ 0.005, ***p ≤ 0.001, ****p ≤ 0.0005 versus baseline; †p ≤ 0.05 versus 3 months PMI; #p ≤ 0.05, ###p ≤ 0.001, ####p ≤ 0.0005 versus baseline + DOB. NS = nonsignificant; other abbreviations as in Figures 1, 2, and 4.