Table 2.
Echocardiographic Parameters for ISO Versus ISO/3AB
| ISO |
ISO/3AB |
p Value | |||
|---|---|---|---|---|---|
| Baseline | 24 h | Baseline | 24 h | ||
| Heart rate, beats/min | 336.4 ± 6.7 | 379.8 ± 8.1 | 347.5 ± 6.4 | 374.1 ± 5.4 | 0.21 |
| Apical wall thickness, mm | 15.9 ± 0.4 | 19.5 ± 0.5 | 15.4 ± 0.2 | 18.5 ± 0.4 | 0.64 |
| Apical strain rate, % | 40.1 ± 1.6 | 24.7 ± 1.5 | 42.7 ± 0.9 | 37.1 ± 1.1 | 0.0004 |
| Apical fractional area shortening, % | 50.0 ± 2.2 | 38.4 ± 2.5 | 46.4 ± 1.2 | 41.2 ± 1.2 | 0.001 |
| Ejection fraction, % | 86.3 ± 1.0 | 82.0 ± 1.5 | 83.6 ± 1.1 | 82.0 ± 1.1 | 0.25 |
Values are mean ± SEM. Echocardiographic changes associated with intraperitoneal administration of isoproterenol alone (ISO: 5 mg/kg, n = 17) and isoproterenol + 3-aminobenzamide (ISO/3AB: 50 mg/kg, n = 17). Analysis is via 2-way analysis of variance, and p values are for time/treatment interaction.