Figure 4.

Open field: reduced locomotor- and exploratory activities and grooming. Locomotor activity, estimated from the total number of quadrant line crossings, was higher in males than in females and lower in both KO and HET than in CTR mice (A). Vertical exploration expressed as the total number of rearing was as well lower in both KO and HET than in CTR mice (B). The number of fecal boli deposited was lower in KO than in CTR (C). Boxes filled in light and dark gray represent data of female and male mice, respectively. (n = 10 CTR, 9 HET, 10 KO). (#p < 0.05, ### p < 0.001).