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. 2018 Jul 18;12:146. doi: 10.3389/fnbeh.2018.00146

Figure 5.

Figure 5

Reactivity to thermal pain: lower pain sensitivity in KO and HET than in CTR mice. Latency to shaking (A,C) and latency to endpoint (B,D) in hot plate 1 (A,B) and hot plate 2 (C,D). In both cohorts of mice, latency to endpoint was longer in both KO and HET than in CTR mice (B,D), whereas latency to hindpaw shaking did not differ between genotypes (A,C). Boxes filled in light and dark gray represent data of female and male mice, respectively. (n = 9 CTR, 12 HET, 6 KO for hot plate 1, n = 7 CTR, 9 HET, 8 KO for hot plate 2). (#p < 0.05, ##p < 0.01).