Figure 3.

¹⁸F-DHMT microPET/CT Imaging and Quantitation of the Myocardial ROS Activity Ratio

(A) Representative micro/PET (top row) and fused microPET/CT (bottom row) images following ¹⁸F-DHMT injection from a control and a matched DOX-treated rat imaged at 4 weeks after chemotherapy initiation (left), and a control and corresponding DOX-treated rat imaged at 6 weeks following chemotherapy initiation (right). Each individual image is scaled to the blood pool SUV. (B) Quantified myocardial-to-blood pool SUV ratios between controls (n = 5) and DOX-treated rats (n = 5) at 4 weeks, and controls (n = 4) and DOX-treated rats (n = 4) at 6 weeks following chemotherapy initiation. (C) Correlation between LVEF and LV ¹⁸F-DHMT uptake (myocardial-to-blood pool SUV), and (D) between LV end-systolic volume and LV ¹⁸F-DHMT uptake (myocardial-to-blood pool SUV) in DOX-treated rats at 6 weeks (n = 4) and matched controls (n = 4). *p < 0.05 between-group difference. Values are expressed as median with interquartile range. LVEF = left ventricular ejection fraction; ROS = reactive oxygen species; SUV = standardized uptake value; other abbreviations as in Figures 1 and 2.