Table 2.

Plasma Furosemide Noncompartmental PK Parameters Following IV Administration

	Cmax (ng/ml)	Tmax (h)	AUClast (h ∙ ng/ml)	AUC∞ (h ∙ ng/ml)	AUCext (%)	λz (1/h)	t½ (h)	V (l)	CL (l/h)
n	15	15	15	15	15	15	15	15	15
Mean	8,580	N/A	13,000	13,200	0.912	0.277	2.55	24.4	6.71
SD	2,540	N/A	4050	4,170	0.631	0.0365	0.339	9.15	2.31
% CV	29.5	N/A	31.1	31.6	69.2	13.2	13.3	37.5	34.5
Geometric mean	8,270	N/A	12,400	12,600	0.729	0.274	2.53	23.2	6.37
Geometric % CV	28.4	N/A	33.3	33.7	82.2	13.3	13.3	31.2	33.7
Minimum	5,060	0.08	6,540	6,600	0.199	0.218	2.00	15.8	3.83
Median	8,230	2.08	12,800	12,900	0.666	0.275	2.52	23.0	6.20
Maximum	13,800	2.08	20,500	20,900	2.47	0.347	3.18	53.1	12.1

λ_z = apparent terminal phase elimination rate constant; AUC = area under the curve; AUC_∞ = plasma concentration to infinity; AUC_ext = percentage of AUC that is extrapolated beyond the last measurable concentration; AUC_last = last measurable plasma concentration; CL = systemic clearance; C_max = peak plasma concentration; CV = coefficient of variation; N/A = not available; t_½ = terminal phase elimination half-life; T_max = time to peak plasma concentration; V = systemic volume of distribution.