Table 5.
Analysis of number of patients needed to biopsy for one high-grade prostate cancer diagnosis
| Demographic | Standard biopsy, No. | Targeted biopsy, No. | NNB for one more high-grade prostate cancer diagnosis by targeted vs standard biopsy |
|---|---|---|---|
| All men | 8.2 | 5.8 | 19.7 |
| MRI suspicion | |||
| Low | 35.2 | 88.0 | -58.7 |
| Moderate | 10.3 | 6.4 | 17.1 |
| High | 2.3 | 1.8 | 9.1 |
| PSA quartiles, ng/mL | |||
| <4.4 | 22.8 | 22.8 | No difference |
| 4.4–6.6 | 10.8 | 8.9 | 49.8 |
| 6.6–10.7 | 10.0 | 6.5 | 18.0 |
| ≥10.7 | 4.0 | 2.6 | 7.8 |
| Prostate volume quartiles, cc | |||
| <38 | 6.3 | 4.0 | 10.5 |
| 38–51 | 7.8 | 5.4 | 17.9 |
| 51–72 | 8.4 | 6.8 | 35.0 |
| ≥72 | 12.1 | 9.4 | 42.5 |
| Age quartiles, y | |||
| <57 | 13.3 | 11.9 | 113 |
| 57–62 | 11.0 | 7.7 | 25.6 |
| 62–67 | 9.9 | 4.9 | 9.9 |
| ≥67 | 5.0 | 4.0 | 20.7 |
| Prior negative biopsy | |||
| Yes | 11.3 | 6.2 | 13.8 |
| No | 6.8 | 5.5 | 28.7 |
*MRI = magnetic resonance imaging; NNB = number of men who need to be biopsied; PSA = prostate-specific antigen.