Table 6.
Analysis of number of patients needed to biopsy for one Gleason 6 cancer diagnosis
| Demographic | Standard biopsy, No. | Targeted biopsy, No. | NNB by target vs standard biopsy to diagnose one fewer Gleason 6 cancer |
|---|---|---|---|
| All men | 4.9 | 6.8 | 17.0 |
| MRI suspicion | |||
| Low | 3.7 | 5.2 | 12.6 |
| Moderate | 4.9 | 6.7 | 18.0 |
| High | 9.9 | 18.2 | 21.8 |
| PSA quartiles, ng/mL | |||
| <4.4 | 3.7 | 4.4 | 25.1 |
| 4.4–6.6 | 4.6 | 5.8 | 22.6 |
| 6.6–10.7 | 5.5 | 8.4 | 15.8 |
| ≥10.7 | 6.4 | 14.8 | 11.4 |
| Prostate volume quartiles, cc | |||
| <38 | 4.4 | 6.3 | 14.9 |
| 38–51 | 4.2 | 6.0 | 14.7 |
| 51–72 | 6.0 | 6.8 | 49.0 |
| ≥72 | 5.2 | 8.8 | 12.8 |
| Age quartiles, y | |||
| <57 | 4.7 | 6.3 | 18.8 |
| 57–62 | 4.2 | 5.8 | 15.3 |
| 62–67 | 5.0 | 6.1 | 28.6 |
| ≥67 | 5.6 | 10.0 | 12.6 |
| Prior negative biopsy | |||
| Yes | 7.3 | 12.6 | 17.2 |
| No | 3.9 | 5.1 | 16.9 |
*MRI = magnetic resonance imaging; NNB = number of men who need to be biopsied; PSA = prostate-specific antigen.