. 2017 May 19;186(1):38–45. doi: 10.1093/aje/kwx054

Table 3.

Age- and Multivariate-Adjusted Hazard Ratios for Rosacea According to Pack-Years of Smoking, Nurses’ Health Study II, 1991–2005

Smoking Status and No. of Pack-Years	No. of Cases	No. of Person-Years	Crude Incidence Rate/100,000 Person-Years	Age-Adjusted		Multivariable-Adjusted^a
Smoking Status and No. of Pack-Years	No. of Cases	No. of Person-Years	Crude Incidence Rate/100,000 Person-Years	HR	95% CI	HR	95% CI
Never smoker	3,586	851,853	421	1.00	Referent	1.00	Referent
Past smoker
<10	821	174,269	471	1.10	1.02, 1.19	1.07	0.99, 1.15
10–24	603	113,896	529	1.18	1.08, 1.29	1.11	1.02, 1.22
≥25	107	16,911	633	1.27	1.05, 1.54	1.18	0.97, 1.43
P_trend				<0.0001		0.003
Current smoker
<10	73	24,446	299	0.87	0.69, 1.10	0.85	0.67, 1.07
10–24	168	67,749	248	0.65	0.56, 0.76	0.64	0.55, 0.75
≥25	104	38,350	271	0.56	0.46, 0.68	0.56	0.46, 0.68
P_trend				<0.0001		<0.0001

Abbreviations: CI, confidence interval; HR, hazard ratio; MET, metabolic equivalent of task.

^a Adjusted for age (years; continuous variable), race/ethnicity (% non-Hispanic white), body mass index (weight (kg)/height (m)²; continuous variable), postmenopausal hormone use (premenopausal, never use, current use, or past use), alcohol drinking (none, or <4.9, 5.0–9.9, 10–14.9, 15–29.9, or ≥30.0 g/day), and physical activity (MET-hours/week, in quintiles).