Figure 6.
Blockade of Ih reduced the resonant frequency of networks. (A) The z-scored time course of the MU firing rate for the duration of an experiment (black). Optogenetic chirps are indicated in gray. After the first epoch of stimulation with control aCSF the perfusion was switched to ZD aCSF. Ten minutes after the addition of ZD-7288, a second epoch of stimulation was applied. The relative activity of MU recorded in L5 (B) and MU recorded outside of L5 (C) for increasing (left) and decreasing (right) frequency stimuli. For chirps in control aCSF (gray) and ZD aCSF (black). The thin black line indicates chance activity levels. With ZD-7288 in the bath, the responses to low-frequency stimuli were increased. Ctrl aCSF, control aCSF. Dashed lines indicate the 95% confidence interval of the median.