Figure 7.
I h played a limited role in resonance when synaptic transmission was suppressed. (A) The z-scored time course of the MU firing rate for the duration of an experiment (black). Optogenetic chirps are indicated in gray. After the first epoch of stimulation with Kyn + Bic aCSF the perfusion was switched to Kyn + Bic + ZD aCSF. Ten minutes after the addition of ZD, a second epoch of stimulation was applied. The relative activity of MU recorded in L5 (B) and MU recorded outside of L5 (C) for increasing (left) and decreasing (right) frequency stimuli. For chirps in Kyn + Bic aCSF (gray) and Kyn + Bic + ZD aCSF (black). The thin black line indicates chance activity levels. The addition of ZD-7288 caused a limited change in the frequency response, indicating that with synaptic transmission suppressed Ih played a small role in the frequency response. Dashed lines indicate the 95% confidence interval of the median.