Table 3.

Multivariable models for neurocognitive outcomes^*

Predictors	Neurocognitive domain
	Task efficiency	Memory	Organization	Emotional regulation
	RR (95% CI)	RR (95% CI)	RR (95% CI)	RR (95% CI)
Chronic conditions
Cardiopulmonary†
No	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Yes	1.27 (1.12 to 1.44)	1.25 (1.06 to 1.48)	1.29 (1.08 to 1.54)	1.34 (1.11 to 1.61)
Endocrine
No	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Yes	1.14 (1.02 to 1.28)	1.17 (1.01 to 1.36)	1.02 (0.86 to 1.20)	1.38 (1.17 to 1.62)
Treatment factors
CRT, per 10 Gy	‡	1.20 (1.16 to 1.24)	1.07 (1.03 to 1.12)	to
Sex†
Male	1.23 (1.17 to 1.29)	–	–	–
Female	1.29 (1.24 to 1.35)	–	–	–
Age at diagnosis†, per 10 Gy, y
1	1.26 (1.21 to 1.31)	–	–	–
5	1.21 (1.18 to 1.24)	–	–	–
10	1.16 (1.13 to 1.19)	–	–	–
15	1.11 (1.06 to 1.17)	–	–	–
20	1.07 (1.00 to 1.14)	–	–	–
Anthracyclines	‡			‡
Years from diagnosis†, per 100mg/m2
15	0.92 (0.86 to 0.98)	–	–	0.83 (0.76 to 0.91)
20	0.95 (0.91 to 0.99)	–	–	0.91 (0.86 to 0.96)
25	0.98 (0.95 to 1.02)	–	–	0.99 (0.95 to 1.04)
30	1.01 (0.96 to 1.08)	–	–	1.08 (1.01 to 1.17)
35	1.05 (0.96 to 1.15)	–	–	1.18 (1.05 to 1.33)
Corticosteroids
No	–	1.00 (reference)	–	1.00 (reference)
Yes	–	1.20 (1.05 to 1.38)	–	1.27 (1.10 to 1.46)

^*Only predictors that have direct effect on neurocognitive outcomes in path analysis are included in log-binomial multivariable regression. CI = confidence interval; CRT = cranial radiation therapy; RR = relative risk.

^†Pulmonary and cardiac conditions were combined in the path analysis due to the low prevalence (n = 92, 1.7 %) of grade 2 or higher pulmonary conditions in the cohort.

^‡Main effects of the treatment factor are not presented due to the presence of interactions with clinical variables.