Table 2.

(A) Clusters of significant ICN-hypoconnectivity in the UCLA cohort. (B) Clusters of significant ICN-hypoconnectivity in the Syracuse cohort

Network	Cluster index	Voxels	P-value	MNI coords			MNI Location
				X	Y	Z
(A) UCLA
ACC/precuneus	4	933	<0.001	−2	48	−4	Paracingulate gyrus
	3	213	0.001	4	26	52	Superior frontal gyrus
	2	147	0.001	18	42	44	Right frontal pole
	1	1	0.002	2	48	−12	mPFC
Comb. executive	2	50	0.001	32	32	−12	Right OFC
	1	28	0.002	−46	44	2	Left frontal pole
DMN	2	185	<0.001	−16	−56	18	Left precuneus
	1	1	0.002	18	−54	24	Right precuneus
Posterior DMN	4	316	<0.001	−14	−56	28	Left precuneus
	3	226	<0.001	2	−16	30	PCC
	2	119	<0.001	6	−52	38	Right precuneus
	1	18	0.002	14	−62	34	Right precuneus
Salience	5	573	<0.001	4	16	28	ACC
	4	402	<0.001	0	50	−4	Paracingulate gyrus
	3	276	0.001	−2	−12	30	ACC, PCC
	2	19	0.002	−12	−36	46	Pre/postcentral gyrus
	1	3	0.002	−32	18	−12	Left OFC
(B) Syracuse
ACC/PRECUN + SAL	2	1715	<0.001	−2	52	−6	mPFC,ACC
	1	95	0.001	−24	52	16	Left frontal pole
DMN	2	154	<0.001	−4	−50	16	PCC
	1	54	0.001	18	−52	18	Precuneus
Posterior DMN	2	243	<0.001	0	−34	22	PCC
	1	4	0.001	−44	−64	52	Left dlOCC
Right executive	2	247	<0.001	44	−54	48	Angular gyrus, right SPL
	1	53	0.001	42	50	10	Right frontal pole
Left executive	2	48	<0.001	−42	−64	52	Left dlOCC
	1	27	0.001	−18	56	22	Left frontal pole

mPFC = medial prefrontal cortex; OFC = orbitofrontal cortex; PCC = posterior cingulate cortex; ACC = anterior cingulate cortex; ACC/PRECUN + SAL = merged ACC/precuneus and salience network; dlOCC = dorsolateral occipital cortex; SPL =  superior parietal lobule.