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. 2017 Nov 2;162(1):146–166. doi: 10.1093/toxsci/kfx235

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Published by Oxford University Press on behalf of the Society of Toxicology 2017. This work is written by US Government employees and is in the public domain in the US.

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Figure 3. — A, ANN probabilities for clastogen classification are graphed for each of 103 chemicals that were evaluated in TK6 cells with the MultiFlow DNA Damage assay. Chemicals are grouped according to class: A, adequately tested; I, inadequately tested; S, top concentration limited by solubility. A series of probabilities are plotted for each chemical, with each point representing a different concentration. A dashed line indicates the threshold value that probability scores had to reach in order to be considered significant. B, ANN probabilities for aneugen classification are graphed for each of 103 chemicals that were evaluated in TK6 cells with the MultiFlow DNA Damage assay. Chemicals are grouped according to class: A, adequately tested; I, inadequately tested; S, top concentration limited by solubility. A series of probabilities are plotted for each chemical, with each point representing a different concentration. A dashed line indicates the threshold value that probability scores had to reach in order to be considered significant.