Figure 3.

Biomarker panel performance in the National Cancer Institute Early Detection Research Network (NCI EDRN) reference set cohort 3. A) Receiver operating characteristic (ROC) curves of the biomarker panel model for differentiating all early-stage cancer from healthy controls in the EDRN reference set (A). B) ROC curves of the biomarker panel in differentiating all cancer from healthy controls in samples without history of diabetes and chronic pancreatitis. The area under the curve was calculated, and its 95% confidence interval was estimated using bootstrapping method. P values are two-sided and based on z test using bootstrap standard error estimate. CI = confidence interval; TFPI = tissue factor pathway inhibitor; TNC = tenascin C.