Table 1.
Characteristics of study subjects in the early-stage TexGen cohort and blinded University of Pittsburgh early-stage cohort*
| Characteristic | Training set–TEXGEN |
Validation set–1 University of Pittsburgh cohort |
|||
|---|---|---|---|---|---|
| PDAC (n = 85) | Healthy controls (n = 30) | PDAC (n = 23) | Healthy controls (n = 17) | Chronic pancreatitis (n = 24) | |
| Sex | |||||
| Male | 46 | 19 | 14 | 6 | 13 |
| Female | 39 | 11 | 9 | 11 | 11 |
| Age, y | |||||
| <50 | 4 | 5 | 3 | 3 | 14 |
| 50–60 | 25 | 12 | 6 | 2 | 3 |
| 61–70 | 28 | 10 | 10 | 6 | 6 |
| 71–80 | 22 | 3 | 2 | 2 | 1 |
| >80 | 6 | – | 2 | 4 | – |
| Histology | |||||
| Adenocarcinoma | 60 | – | 15 | – | – |
| Infiltrating ductal carcinoma | 24 | – | 8 | – | – |
| Adenocarcinoma spindle cell | 1 | – | 0 | – | – |
| Stage | |||||
| I | 25 | – | – | – | |
| IA | 1 | – | – | – | |
| IB | 2 | – | – | – | |
| II | 33 | – | – | – | |
| IIA | 2 | – | – | – | |
| IIB | 22 | – | 23 | – | – |
| Alcohol history | |||||
| Current | 28 | 13 | 9 | 4 | 8 |
| Former | 18 | 4 | 7 | 5 | 12 |
| Never | 39 | 13 | 6 | 7 | 4 |
| Unknown | – | – | 1 | 1 | 0 |
| Smoking history | |||||
| Current | 7 | 0 | 8 | 4 | 12 |
| Former | 44 | 11 | 10 | 6 | 6 |
| Never | 34 | 19 | 5 | 7 | 6 |
| Diabetes history | |||||
| Yes | 21 | 5 | 5 | 4 | 6 |
| No | 64 | 25 | 18 | 13 | 18 |
| Site | |||||
| Body | 6 | – | 0 | – | – |
| Head | 68 | – | 19 | – | – |
| Pancreas overlapping lesion | 6 | – | 3 | – | – |
| Tail | 2 | – | 0 | – | – |
| Other specified parts | 3 | – | 1 | – | – |
| Stage | |||||
| Direct extension | 32 | – | – | – | – |
| Direct extension + lymph node | 16 | – | – | – | – |
| Distant | 3 | – | – | – | – |
| Localized | 25 | – | – | – | – |
| Regional lymph node involvement | 3 | – | – | – | – |
| Unstaged | 6 | – | – | – | – |
| TNM stage | |||||
| T1N1Mx | – | – | 2 | – | – |
| T2N1Mx | – | – | 1 | – | – |
| T3N0Mx | – | – | 1 | – | – |
| T3N1Mx | – | – | 14 | – | – |
| T3N1BMx | – | – | 5 | – | – |
*
PDAC = pancreatic ductal adenocarcinoma.