Figure 6.

PEA15 expression in human lung cancer cases. A) Comparison of PEA15 mRNA expression between normal (N) and malignant (T) lung tissues in lung adenocarcinoma (AD), and squamous cell carcinoma (SCC) lung cancers in the The Cancer Genome Atlas database (n = 59 for N, 517 for T in AD, and 51 for N, 501 for T in SCC). Each symbol represents a single case. Bars represent median values. B) PEA15 expression in normal and malignant lung tissues. Representative PEA15 immunostaining of lung cancers and adjacent normal lung tissues are in the upper panels, and PEA15 immunohistochemical staining of T and N are compared in the lower panels. Scale bars = 200 µm. C) Association between PEA15 immunohistochemical expression and stage. D) Kaplan-Meier analysis of overall survival between human lung cancer cases stratified by PEA15 immunohistochemical expression (high, intermediate, and low). Error bars display standard deviation. The P values were computed using t test (A and B) with multiple comparison adjustment by Tukey’s method (C) and log-rank test (D). The trend test was also performed (C). All statistical tests were two-sided. AD = adenocarcinoma; N = normal; SCC = squamous cell carcinoma; T = malignant.