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. 2017 Feb 10;109(6):djw297. doi: 10.1093/jnci/djw297

Figure 8.

Figure 8.

Antineoplastic activity of the CDK2/9 inhibitor CYC065. A) Dose-response curves for murine (ED1 and LKR13) and human (H522 and Hop62) lung cancer cells after CYC065 or vehicle treatments. B) Percentage of apoptotic cells after CYC065 treatment in murine (ED1 and LKR13) and human (H522 and Hop62) lung cancer cells. C) Percentages of cells undergoing multipolar anaphase after CYC065 or vehicle treatments of murine (ED1) and human (Hop62) lung cancer cells. The vehicle control lung cancer cell shown is bipolar, and in marked contrast the CYC065 treated cells are, respectively, shown with three (right panel) or four (middle panel) spindle poles. The blue signal is DAPI staining, and the red signal is α-tubulin staining. Scale bars = 5 µm. Error bars are standard deviation. The P values were computed using t test with multiple comparisons by Dunnet's method. All statistical tests were two-sided.