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The framework for the relationship of filter ventilation to the increased rate of adenocarcinoma. The placement and increase of filter ventilation lead to higher levels of mutagens and carcinogens, compensation with the greater depth of inhalation, and deposition of smoke that increases exposures to in the peripheral portion of the lungs. Thus, smokers who smoke low-tar cigarettes have developed a greater risk for adenocarcinoma of the lung. TSNAs = tobacco-specific nitrosamines.
