Table 2.
Echocardiography
| Control (n = 14) | UCn2 (n = 12) | UCn3 (n = 12) | p Value | |
|---|---|---|---|---|
| EF, % | 65 ± 2 | 81 ± 1 | 74 ± 1∗ | <0.0001 |
| EDD, mm | 3.9 ± 0.1 | 3.3 ± 0.1 | 3.7 ± 0.1† | <0.0001 |
| ESD, mm | 2.5 ± 0.1 | 1.7 ± 0.1 | 2.1 ± 0.1‡ | <0.0001 |
| VCFc, circ/s | 23 ± 1 | 36 ± 1 | 28 ± 1§ | <0.0001 |
| HR, beats/min | 532 ± 7 | 544 ± 8 | 534 ± 9 | 0.90 |
| MV E, mm/s | 714 ± 45 | 894 ± 31 | 866 ± 36 | 0.004 |
| E/A | 1.7 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 0.62 |
Values are mean ± SE. Data were obtained 9.0 ± 0.2 weeks after IV delivery of AAV8.UCn2 or AAV8.UCn3 (both at 1.9 × 1013 gc/kg) or saline (control). p Values from 1-way ANOVA.
Group differences were seen in UCn2 versus UCn3: *p = 0.0013 versus UCn2; †p = 0.0007 versus UCn2; ‡p < 0.0002; §p < 0.0001 versus UCn2; analysis by Sidak multiple comparison test with correction.
Circ = circumference; E/A = ratio of passive to active mitral inflow velocity; EDD = end-diastolic diameter; EF = ejection fraction; ESD = end-systolic diameter; MV E = passive mitral inflow velocity; VCFc = velocity of circumferential fiber shortening (corrected for heart rate); other abbreviations as in Table 1.