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The function of Hsp70 in suppressing apoptosis after ischemic stroke. Hsp70 protect cytochrome c (Cyt C) release from mitochondria. Apoptosome formation is interrupted by Hsp70 binding to Cyt C and procaspase-9 (Casp 9). Hsp70 also prevents release of AIF and Samc/DIABLO from mitochondria. Hsp70 can also prevent the death receptor signaling pathway. Arrows indicated increased activity or amount, and the barred ends indicates steps that are interrupted or reduced when Hsp70 is induced.
