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Hsp70 interrupts trafficking Fas of dynamin during stroke. Stroke displays increasing membrane Fas expression, presumably because of its trafficking from the Golgi apparatus by dynamin. Fas ligand (FasL), also increased after stroke, binds Fas and activates caspase-8 through engagement of its adaptor molecule Fas associated death domain (FADD), which then leads to cell death through apoptosis. Induction of Hsp70 may prevent Fas membrane expression by interrupting dynamin.
