Table 1. Descriptive statistics for the age at menarche (AAM, n = 44,367) and natural menopause (ANM, n = 17,100) analytic samples.

Study		Sample Size	Median Age at report (years)	Median Birth Year	Median* AAM or ANM (years)	Obesity (%)
MENARCHE
AfA	ARIC	2,056	53	1935	13	48
	EAGLE BioVU	656	41	1972	12	51
	CARDIA	990	25	1960	12	21
	MEC	4,410	59	1933	-	39
	BioME**	373	47	1966	12	48
	WHI**	11,724	61	1935	-	51
H/L	HCHS/SOL	7,027	48	1962	13	45
	MEC	859	59	1934	-	32
	SIGMA-Diab**	910	59	1935	-	49
	SIGMA-Cont**	910	59	1934	-	17
	BioME**	512	49	1964	12	45
	WHI	5,129	59	1936	-	37
AsA	MEC-Hawaiian	1,364	54	1939	-	37
	MEC-Japanese	3,725	59	1935	-	10
	WHI	3,184	63	1933	-	12
AI/AN	WHI	538	61	1935	-	45
Study		Sample Size	Median Age at report (years)	Median Birth Year	Median* AAM or ANM (years)	Obesity (%)	Current Smoking (%)
NATURAL MENOPAUSE
AfA	ARIC	569	56	1931	49	49	25
	CARDIA	150	54	1956	49	63	18
	HyperGen	189	57	1940	47	63	20
	MEC	1,598	62	1930	-	38	16
	MESA	583	65	1936	49	52	17
	WHI**	4,209	62	1934	50	50	12
H/L	HCHS/SOL	1,940	58	1952	49	49	16
	MEC	416	60	1934	-	31	12
	SIGMA-Diab**	225	60	1933	-	31	9
	SIGMA-Cont**	61	61	1932	-	20	8
	MESA	509	63	1938	49	51	12
	BioME**	93	55	1958	50	55	-
	WHI	2,027	60	1936	50	36	6
AsA	MEC-Hawaiian	567	57	1936	-	33	20
	MEC-Japanese	1,822	61	1932	-	7	8
	MESA	299	65	1936	50	5	2
	WHI	1,659	63	1932	50	10	4
AI/AN	WHI	184	61	1935	50	41	10

*Median estimates not available for MEC or WHI for AAM, or MEC for ANM, due to their categorical ascertainment of these traits (see S1 and S2 Text for more information on the pseudo-continuous recoding of these traits).

**Studies which include imputed MetaboChip SNP data.

Abbreviations: AfA = African American, AI/AN = American Indian/Alaskan Native, AsA = Asian American, Cont = Type 2 Diabetes Controls, Diab = Type 2 Diabetes Cases, H/L = Hispanic/Latina