Skip to main content
. 2018 Jul 25;13(7):e0200478. doi: 10.1371/journal.pone.0200478

Fig 2. ZIKV binding and neutralization potency by DENV immune sera.

Fig 2

(A) Binding capacity of DENV immune sera in DENV-1 early group (n = 10), DENV-1 late group (n = 10), DENV-3 early group (n = 10), DENV-3 late group (n = 10) or DENV-naïve donors (n = 3) were detected by ELISA using plates coated with ZIKV culture supernatant. The binding activity was presented as the optical density value at 450nm (OD450). (B) Summary of ELISA results as mean endpoint titers. Statistical significances were identified using the unpaired two-tailed Student’s t test. “**” represents p<0.01, and “***” represents p<0.001. (C) Neutralization potency of DENV-immune sera in each group and three DENV-naïve sera against ZIKV was assessed by performing a plaque-forming assay on Vero cells with 2-fold diluted serum samples.