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. 2018 Jul 25;13(7):e0201199. doi: 10.1371/journal.pone.0201199

Table 4. Clinical characteristics of patients with and without the recurrence of AF.

Variables PAF non-PAF
No Recurrence AF Recurrence P Value No Recurrence AF Recurrence P Value
Patients, n (%) 50 23 26 19
Male sex, n (%) 42(84) 19(82.6) 1 22(84.6) 19(100) 0.13
Age, years (IQR) 57.0(49.0–62.0) 59.0(54.5–62.0) 0.56 58.5(53.5–62) 56.0(48.5–62) 0.39
BMI, kg/m2 (IQR) 24.3(22.1–27.9) 22.3(21.2–24.4) 0.015* 23.7(21.4–26.1) 24.5(21.4–26.1) 0.68
Duration of AF, months (IQR) 31.0(10.5–72.0) 36.0(4.5–60.0) 0.42 15.5(5.3–36.0) 36.0(20.5–72.0) 0.008*
Hypertension, n (%) 17(34) 6(26.1) 0.594 5(19.2) 9(47.4) 0.057
Diabetes mellitus, n (%) 4(8) 3(13.0) 0.671 1(3.8) 6(15.8) 0.295
Stroke, n (%) 2(4) 3(13.0) 0.317 2(7.7) 3(15.8) 0.636
History of TCM, n (%) 4(8) 1(4.3) 1 1(3.8) 5(15.8) 0.295
Pre-ablation anti-arrhythmic drugs
    Class Ⅰ AAD, n (%) 26(52) 11(47.8) 0.804 7(27.0) 2(10.5) 0.264
    Class Ⅲ AAD, n (%) 1(2.0) 0(0.0) 1 1(3.8) 0(0.0) 1
    βblocker, n (%) 20(40) 7(30.4) 0.602 12(46.1) 11(57.9) 0.55
    ACEI/ARB, n (%) 15(30) 3(13.0) 0.151 7(26.9) 9(47.4) 0.212
Statin, n (%) 9(18) 3(13.0) 0.74 6(23.1) 8(36.8) 0.34
LV ejection fraction, % (IQR) 69.0(65.0–72.0) 67.0(65.0–70.0) 0.38 63.5(60.0–65.8) 64.0(54.5–68.0) 0.94
LVDd mm (IQR) 50.0(45.3–51.8) 48.0(46.0–52.5) 0.97 48.0(45.0–50.8) 48.0(46.5–52.0) 0.55
Left atrial anteroposterior echocardiographic dimension, mm (IQR) 40.0(36.0–42.8) 40.0(36.0–42.5) 1 42(37.3–45.5) 41(39.5–46.0) 0.49
NT proBNP, pg/ml (IQR) 60.5(24.8–146.0) 70.0(54.8–108.5) 0.35 422(322–671) 375(190–928) 0.99

Data are n (%), and median (IQR; 25%―75% interquartile range).

* significant difference

AAD, anti-arrhythmic drug; ACEI, angiotensin converting enzyme inhibitor; AF, atrial fibrillation; ARB, angiotensin II receptor blocker; BMI, body mass index; LV, left ventricle; LVDd, left ventricular end-diastolic diameter; non-PAF, non-paroxysmal atrial fibrillation; PAF, paroxysmal atrial fibrillation; TCM, tachycardia-induced cardiomyopathy