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. 2018 Jul 25;13(7):e0201076. doi: 10.1371/journal.pone.0201076

Fig 1. The process of nAUC ratio value estimation.

Fig 1

(a) ΔR2* curve and AUC of SPION and Dotarem for unnormalized DSC-MRI signal of normal rat. Corresponding AUC ratio values were 0.613 and 0.596 for right and left hemispheres, respectively. (b) ΔR2* curve and AUC of SPION and Dotarem for normalized DSC-MRI signals of normal rat. Corresponding nAUC ratio values were 1 and 0.971 for right and left hemispheres, respectively. (c) ΔR2* curve and AUC of SPION and Dotarem for unnormalized DSC-MRI signal of tMCAO rat. Corresponding AUC ratio values were 0.598 and 0.823 for contralateral and ipsilateral hemisphere, respectively. (d) ΔR2* curve and AUC of SPION and Dotarem for normalized DSC-MRI signal of tMCAO rat. Corresponding nAUC ratio values were 1 and 1.376 for right and left hemispheres, respectively. Black arrows in (c) represent the second peak from recirculation from SPION DSC-MRI times curves.