TABLE.

Clinical and Neuroimaging Comparison of NAD and FAHN

	NAD	FAHN
Neuromotor features
Ataxia, dysmetria	Profound	Profound
Dystonia	Mild	Mild-severe
Spastic quadriplegia	Prominent	Prominent
Pyramidal tract signs	Prominent	Prominent
Axial hypotonia	Prominent	Not noted
Neuro-ophthalmologic features
Optic atrophy	Prominent	Mild-severe
Nystagmus	Present	Present
Acquired strabismus	Present	Present
Neuroimaging findings
Cerebellar atrophy	Prominent	Prominent
Brainstem atrophy	Absent	Prominent
Globus pallidus iron deposition	Variable	Variable
Other features
Seizures	Occasional	Occasional
Peripheral neuropathy	Prominent	Absent
Neuroaxonal spheroids	Prominent	???
Excessive beta activity (EEG)	Prominent	Present