Table 1.
Baseline characteristics.
| Borderline lumpectomy- eligible patients |
Locally- advanced patients |
P-value | Total N (%) |
|
|---|---|---|---|---|
| IIA (T2N0), IIB, IIIA (T3N1) N (%) |
IIIA (T0- 3N2), IIIB, IIIC N (%) |
|||
| Age (years) | .0003 | |||
| <50 | 44,824 (46) | 9,289 (45) | 54,113 (46) | |
| 50–54 | 19,150 (20) | 4,078 (20) | 23,228 (20) | |
| 55–59 | 17,676 (18) | 4,009 (19) | 21,685 (18) | |
| 60–64 | 15,716 (16) | 3,344 (16) | 19,060 (16) | |
| Race** | <.0001 | |||
| White non-Hispanic | 66,293 (73) | 13,135 (68) | 79,428 (72) | |
| Black non-Hispanic | 13,681 (15) | 3,726 (19) | 17,407 (16) | |
| Hispanic | 6,884 (8) | 1,721 (9) | 8,605 (8) | |
| Other | 4,570 (5) | 795 (4) | 5,365 (5) | |
| Insurance status | <.0001 | |||
| Private | 78,113 (80) | 14,914 (72) | 93,027 (79) | |
| Medicaid | 12,205 (13) | 3,828 (19) | 16,033 (14) | |
| Other government | 1,361 (1) | 284 (1) | 1,645 (1) | |
| None or unknown | 5,687 (6) | 1,694 (8) | 7,381 (6) | |
| Year of Diagnosis | <.0001 | |||
| 2006 | 7,359 (8) | 2,185 (11) | 9,544 (8) | |
| 2007 | 8,968 (9) | 2,516 (12) | 11,484 (10) | |
| 2008 | 13,345 (14) | 3,198 (15) | 16,543 (14) | |
| 2009 | 15,222 (16) | 3,178 (15) | 18,400 (16) | |
| 2010 | 17,188 (18) | 3,420 (17) | 20,608 (18) | |
| 2011 | 17,769 (18) | 3,232 (16) | 21,001 (18) | |
| 2012 | 17,515 (18) | 2,991 (14) | 20,506 (17) | |
| Charlson/Deyo Comorbidity Score | .09 | |||
| 0 | 86,755 (89) | 18,369 (89) | 105,124 (89) | |
| 1 | 9,260 (10) | 2,031 (10) | 11,291 (10) | |
| 2+ | 1,351 (1) | 320 (2) | 1,671 (1) | |
| Facility location* | <.0001 | |||
| South | 37,203 (38) | 8,416 (41) | 45,619 (39) | |
| Midwest | 26,188 (27) | 5,313 (26) | 31,501 (27) | |
| Northeast | 17,048 (18) | 3,634 (18) | 20,682 (18) | |
| West | 16,927 (17) | 3,357 (16) | 20,284 (17) | |
| Facility type | <.0001 | |||
| Academic/research | 32,501 (33) | 6,867 (33) | 39,368 (33) | |
| Comprehensive community cancer program | 55,206 (57) | 11,448 (55) | 66,654 (56) | |
| Community cancer program | 9,659 (10) | 2,405 (12) | 12,064 (10) | |
| Population density | .04 | |||
| Non-rural | 92,698 (98) | 19,646 (98) | 112,344 (98) | |
| Rural | 1,517 (2) | 362 (2) | 1,879 (2) | |
| Tumor grade | <.0001 | |||
| 1 | 8,457 (9) | 952 (5) | 9,409 (8) | |
| 2 | 34,790 (38) | 6,303 (33) | 41,093 (37) | |
| 3+ | 49,316 (53) | 11,808 (62) | 61,124 (55) | |
| HR Summary (Years 2006–2009) | <.0001 | |||
| ER+ or PR+ | 13,859 (32) | 4,076 (38) | 36,858 (67) | |
| ER and PR− or borderline | 30,134 (69) | 6,724 (62) | 17,935 (33) | |
| HR/HER2 summary (Years 2010–2012) | <.0001 | |||
| HR+/HER2− | 29,420 (60) | 4,473 (49) | 33,893 (58) | |
| HR+/HER2+ | 6,618 (13) | 1,464 (16) | 8,082 (14) | |
| HR−/HER2+ | 3,281 (7) | 1,081 (12) | 4,362 (8) | |
| HR−/HER2− | 10,045 (20) | 2,061 (23) | 12,106 (21) | |
| AJCC Clinical Stage | --- | |||
| IIA (T2N0 only) | 58,781 (60) | - | 58,781 (50) | |
| IIB | 30,636 (32) | - | 30,636 (26) | |
| IIIA (T3N1 only) | 7,949 (8) | - | 7,949 (7) | |
| IIIA (T0-3N2 only) | - | 8,024 (39) | 8,024 (7) | |
| IIIB non-inflammatory | - | 4,884 (24) | 4,884 (4) | |
| IIIC non-inflammatory | - | 4,221 (20) | 4,221 (4) | |
| Inflammatory (T4d) | - | 3,591 (17) | 3,591 (3) | |
| Histology | ||||
| Invasive ductal carcinoma | 82,992 (85) | 17,030 (82) | <.0001 | 100,022 (85) |
| Invasive lobular carcinoma | 9,101 (9) | 1,457 (7) | 10,558 (9) | |
| Mixed ductal and lobular | 5,229 (5) | 944 (5) | 6,173 (5) | |
| Inflammatory | 44 (<1) | 1,289 (6) | 1,333 (1) | |
| Laterality | <.0001 | |||
| Unilateral | 97,331 (>99) | 20,697 (>99) | 118,028 (>99) | |
| Bilateral | 35 (<1) | 23 (<1) | 58 (<1) |
Abbreviations: AJCC, American Joint Committee on Cancer. HR, Hormone Receptor. HER2, Human Epidermal Growth Factor Receptor 2.
Approximately 6% of patients had missing information on race.
South includes Washington DC, Delaware, Florida, Georgia, Maryland, North Carolina, South Carolina, Virginia, West Virginia, Alabama, Kentucky, Mississippi, Tennessee, Arkansas, Louisiana, Oklahoma, and Texas; Midwest includes Illinois, Indiana, Michigan, Ohio, Wisconsin, Iowa, Kansas, Minnesota, Missouri, North Dakota, Nebraska, South Dakota; Northeast includes Connecticut, Massachusetts, Maine, New Hampshire, Rhode Island, Vermont, New Jersey, New York, and Pennsylvania; West includes Arizona, Colorado, Idaho, Montana, New Mexico, Nevada, Utah, Wyoming, Alaska, California, Hawaii, Oregon, and Washington.