Table I.
Top 10 GO biological processes for 1,180 differentially methylated genes.
| GO term | Count | Fold enrichment | P-value | FDR | Genes |
|---|---|---|---|---|---|
| Regulation of nucleotide biosynthetic process | 18 | 3.37 | <0.001 | <0.01 | ACR, ADCY3, GNAZ, AVP, LHCGR, ABCA1, SSTR5, S1PR3, ADRB2, HRH3, HTR7, GIPR, GNAS, NOS3, ADM2, GUCA2B, GLP1R, GNG7 |
| Regulation of cAMP biosynthetic process | 16 | 3.34 | <0.001 | <0.01 | ACR, ADCY3, GNAZ, AVP, LHCGR, ABCA1, SSTR5, S1PR3, ADRB2, HRH3, HTR7, GIPR, GNAS, ADM2, GLP1R, GNG7 |
| Multicellular organism reproduction | 45 | 1.84 | <0.001 | <0.01 | ACR, NANOS3, RAD51C, PCDHA8, H1FNT, SPATA20, FKBP6, LHCGR, PCDHGA9, ADAD1, MAEL, HP, BCL2L1, SOHLH1, SOHLH2, KRT9, VDR, WNT4, POU5F2, NOS3, DAZL, TGM4, FAS, PIWIL4, DND1, SPATA3, B4GALNT1, PCDHGA12, EGFR, B4GALT1, AVP, PCDHGA11, MAK, TNP1, CELSR2, THEG, KDR, APRT, LEP, REC8, ESR2, TXNDC2, P2RX1, TXNDC8, VEGFA |
| Regulation of lyase activity | 15 | 3.28 | <0.001 | <0.01 | ACR, ADCY3, GNAZ, LHCGR, SSTR5, S1PR3, ADRB2, HRH3, HTR7, GIPR, GNAS, NOS3, ADM2, GLP1R, GNG7 |
| cAMP-mediated signaling | 15 | 3.13 | <0.001 | <0.01 | ADCY3, GNAZ, LHCGR, RIMS2, LEP, SSTR5, S1PR3, ADRB2, HTR7, GIPR, GNAS, ADM2, GLP2R, MC3R, GLP1R |
| Regulation of adenylate cyclase activity | 14 | 3.26 | <0.001 | <0.01 | ACR, ADCY3, GNAZ, LHCGR, SSTR5, S1PR3, ADRB2, HRH3, HTR7, GIPR, GNAS, ADM2, GLP1R, GNG7 |
| Sexual reproduction | 38 | 1.85 | <0.001 | <0.01 | ACR, NANOS3, RAD51C, PCDHA8, H1FNT, SPATA20, FKBP6, PCDHGA9, ADAD1, MAEL, HP, BCL2L1, SYCP2, SOHLH1, SOHLH2, KRT9, WNT4, POU5F2, CD4, NOS3, DAZL, FAS, PIWIL4, DND1, SPATA3, B4GALNT1, PCDHGA12, B4GALT1, PCDHGA11, MAK, TNP1, CELSR2, THEG, LEP, REC8, TXNDC2, ADAM1A, TXNDC8 |
| G-protein signaling, coupled to cyclic nucleotide second messenger | 14 | 3.18 | <0.001 | <0.01 | ADCY3, GNAZ, LHCGR, SSTR5, S1PR3, ADRB2, HRH1, HTR7, GIPR, GNAS, ADM2, GLP2R, MC3R, GLP1R |
| Antigen receptor-mediated signaling pathway | 9 | 4.67 | <0.001 | <0.01 | PTPRC, LAT2, CD19, LAX1, CD247, LCK, ZAP70, CACNB4, SKAP1 |
| Spermatogenesis | 28 | 2.05 | <0.001 | <0.01 | NANOS3, RAD51C, H1FNT, SPATA20, PCDHA8, FKBP6, ADAD1, PCDHGA9, MAEL, HP, BCL2L1, SOHLH1, SOHLH2, KRT9, POU5F2, FAS, SPATA3, PIWIL4, B4GALNT1, PCDHGA12, PCDHGA11, MAK, TNP1, CELSR2, THEG, REC8, TXNDC2, TXNDC8 |
cAMP, cyclic adenosine monophosphate; FDR, false discovery rate; GO, Gene Ontology.