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. 2018 May 8;18(1):16–24. doi: 10.3892/mmr.2018.8987

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Increased KCNQ1OT1 expression levels are observed in human cataract lens posterior capsular samples and in TGF-β2 induced cataract cell models. (A) KCNQ1OT1 was upregulated in 90% (27/30) tissue specimens with cataract as detected by RT-qPCR and the 2^−ΔΔCq method. (B) KCNQ1OT1 was significantly upregulated in tissue specimens with cataract as detected by RT-qPCR, **P<0.01 vs. non-cataract group. (C) KCNQ1OT1 was elevated in SRA01/04 cells with the presence of TGF-β2 as observed via RT-qPCR, **P<0.01 vs. control group. All data were presented as the mean ± standard deviation from three independent experiments. ID, identification; KCNQ1OT1, potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; TGF-β2, transforming growth factor-β2.