Table I.
Pathways enriched with DEGs in lung samples from mice with MODS compared with healthy controls.
| A, Pathways that upregulated DEGs in lung samples from MODS mice were enriched in | |||
|---|---|---|---|
| Pathway | P-value | Gene count | DEGs |
| mmu04060: Cytokine-cytokine receptor interaction | 7.75×10−22 | 52 | Il17Ra, Cxcl10, Il18Rap, Cd40, Osm, Inhba, Tnfrsf9, Ccr7, Cxcl1, IL-6… |
| mmu04062: Chemokine signaling pathway | 2.32×10−16 | 39 | Cxcl1, Cxcl10, Stat1, Ccr5, Cxcl13, Cxcl16, Ccr2, Jak2, Jak3, Xcl1… |
| mmu04620: Toll-like receptor signaling pathway | 4.06×10−12 | 25 | Ccl3, Tnf, Cxcl10, Myd88, IL-6, Cd40, Stat1, Ripk1, Irf7, Cd14… |
| mmu04621: NOD-like receptor signaling pathway | 8.60×10−11 | 19 | Cxcl1, IL-6, Tnf, Ccl2, Cxcl2, Ccl8, Nfkbia, Nlrp3, Ccl5, Ccl7… |
| mmu04630: Jak-STAT signaling pathway | 7.80×10−7 | 23 | Csf3, Socs1, Pim1, Stat1, Il7R, Stat2, Csf2Rb, Jak2, Pik3R5, Jak3… |
| B, Pathways that downregulated DEGs in lung samples from MODS mice were enriched in | |||
| Pathway | P-value | Gene count | DEGs |
| mmu00982: Drug metabolism | 5.02×10−8 | 12 | Gstm1, Gsta2, Gsta3, Cyp2D22, Adh1, Fmo1, Fmo2, Fmo3, Maob, Aldh3A1… |
| mmu00980: Metabolism of xenobiotics by cytochrome P450 | 1.68×10−6 | 10 | Gstm1, Gsta2, Gsta3, Cyp2F2, Cyp1A1, Adh1, Gstt1, Ephx1, Cyp2E1, Aldh3A1 |
| mmu04512: ECM-receptor interaction | 5.56×10−4 | 8 | Lama2, Col4A4, Tnxb, Npnt, Itga8, Vtn, Thbs3, Chad |
| mmu05414: Dilated cardiomyopathy | 1.03×10−3 | 8 | Lama2, Actc1, Adrb1, Adcy8, Pln, Itga8, Myh7, Tnni3 |
| mmu00340: Histidine metabolism | 8.94×10−3 | 4 | Hnmt, Acy3, Maob, Aldh3A1 |
DEGs, differentially expressed genes; MODS, multiple organ dysfunction syndrome. DEGs were listed in the table based on P-value and |log2 FC| value of these DEGs.