Table II.
Pathways enriched with DEGs in liver samples from mice with MODS compared with healthy controls.
| A, Pathways that upregulated DEGs in liver samples from MODS mice were enriched in | |||
|---|---|---|---|
| Pathway | P-value | Gene count | DEGs |
| mmu04630: Jak-STAT signaling pathway | 1.36×10−2 | 6 | Irf9, Osmr, Socs3, Il13Ra1, Stat1, Stat3 |
| mmu04060: Cytokine-cytokine receptor interaction | 2.60×10−2 | 7 | Inhbb, Cxcl1, Tnfrsf1A, Osmr, Il13Ra1, Il17Ra, Cxcl10 |
| mmu04115: p53 signaling pathway | 2.67×10−2 | 4 | Rrm2, Serpine1, Gadd45B, Gadd45A |
| mmu04010: MAPK signaling pathway | 3.70×10−2 | 7 | Tnfrsf1A, Jun, Pla2G12A, Fgf21, Gadd45B, Gadd45A, Dusp6 |
| B, Pathways that downregulated DEGs in liver samples from MODS mice were enriched in | |||
| Pathway | P-value | Gene count | DEGs |
| mmu00140: Steroid hormone biosynthesis | 5.43×10−4 | 4 | Hsd3B2, Cyp7A1, Hsd3B5, Srd5A1 |
| mmu00910: Nitrogen metabolism | 3.08×10−3 | 3 | Car5A, Car1, Car3 |
| mmu00150: Androgen and estrogen metabolism | 6.29×10−3 | 3 | Hsd3B2, Hsd3B5, Srd5A1 |
DEGs, differentially expressed genes; MODS, multiple organ dysfunction syndrome.