Table III.
Pathways enriched with DEGs in kidney samples from mice with MODS compared with healthy controls.
| A, Pathways that upregulated DEGs in kidney samples from MODS mice were enriched in | |||
|---|---|---|---|
| Pathway | P-value | Gene count | DEGs |
| mmu04010: MAPK signaling pathway | 8.18×10−4 | 10 | Dusp5, Fos, Dusp4, Dusp1, Jun, Nr4A1, Fgf21, Gadd45A, Myc, Ddit3 |
| mmu04350: TGF-β signaling pathway | 9.34×10−3 | 5 | Inhbb, Smad1, Thbs1, Myc, Bmp6 |
| mmu04115: p53 signaling pathway | 2.80×10−2 | 4 | Cdkn1A, Pmaip1, Thbs1, Gadd45A |
| mmu05200: Pathways in cancer | 3.33×10−2 | 8 | Fos, Cdkn1A, IL-6, Ptgs2, Jun, Fgf21, Myc, Stat3 |
| mmu04610: Complement and coagulation cascades | 3.46×10−2 | 4 | Fgg, Thbd, Fga, F3 |
| B, Pathways that downregulated DEGs in kidney samples from MODS mice were enriched in | |||
| Pathway | P-value | Gene count | DEGs |
| mmu03320: PPAR signaling pathway | 2.75×10−2 | 3 | Ucp1, Adipoq, Fabp5 |
| mmu00900: Terpenoid backbone biosynthesis | 4.54×10−2 | 2 | Mvd, Idi1 |
DEGs, differentially expressed genes; MODS, multiple organ dysfunction syndrome.