Table IV.
Top 20 DEG nodes from mice with MODS demonstrating the highest degrees in PPI networks.
| A, Top 20 DEG nodes with the highest degrees in the lung PPI network | |
|---|---|
| Node | Degree |
| Stat1 | 99 |
| Tnf | 71 |
| IL-6 | 64 |
| Ccr7 | 57 |
| Cxcl10 | 54 |
| Irf1 | 50 |
| Mmp9 | 47 |
| Irf7 | 46 |
| Cxcr2 | 46 |
| Gbp2 | 45 |
| Ccr5 | 44 |
| Ifit1 | 43 |
| Ccr1 | 43 |
| Ifit3 | 42 |
| Ccr2 | 42 |
| Oasl2 | 41 |
| Cxcr6 | 41 |
| Icam1 | 41 |
| Oasl1 | 40 |
| Tyrobp | 40 |
| B, Top 20 DEG nodes with the highest degrees in the liver PPI network | |
| Node | Degree |
| Jun | 16 |
| Stat3 | 16 |
| Stat1 | 16 |
| Icam1 | 12 |
| Gbp2 | 11 |
| Cxcl10 | 11 |
| Irf9 | 10 |
| Egr1 | 9 |
| Cyp7a1 | 9 |
| Sirt1 | 8 |
| Ifit1 | 8 |
| Usp18 | 8 |
| Ifit3 | 8 |
| Hsd3b5 | 8 |
| Cyp2b10 | 8 |
| Cyp3a13 | 7 |
| Rsad2 | 7 |
| Irgm2 | 7 |
| Saa1 | 7 |
| Saa2 | 7 |
| C, Top 20 DEG nodes with the highest degrees in the kidney PPI network | |
| Node | Degree |
| Jun | 28 |
| Fos | 27 |
| IL-6 | 23 |
| Myc | 20 |
| Egr1 | 20 |
| Stat3 | 17 |
| Atf3 | 14 |
| Sirt1 | 14 |
| Ptgs2 | 14 |
| Adipoq | 13 |
| Cdkn1a | 12 |
| Zfp36 | 11 |
| Btg2 | 10 |
| Hmox1 | 10 |
| Cebpb | 10 |
| Junb | 9 |
| Egr2 | 9 |
| Icam1 | 8 |
| Ddit3 | 8 |
| Retn | 7 |
| Klf4 | 7 |
DEGs, differentially expressed genes; MODS, multiple organ dysfunction syndrome; PPI, protein-protein interaction.