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. 2018 May 23;18(1):789–798. doi: 10.3892/mmr.2018.9062

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Pretreatment with RS decreases caspase-9 and cyt c mRNA expression, and increases UCP2 and PPAR-γ mRNA expression following OGD/R damage. Cardiomyocytes were divided into the following groups: Control, control + siPPAR-γ, OGD/R, OGD/R + siPPAR-γ, RS + OGD/R, RS + OGD/R + siPPAR-γ, ATR + RS + OGD/R, ATR + RS + OGD/R + siPPAR-γ. Reverse transcription-quantitative polymerase chain reaction was performed to analyze the mRNA expression levels of (A) caspase-9, (B) cyt c, (C) UCP2 and (D) PPAR-γ in cardiomyocytes. *P<0.05 and ***P<0.001 vs. the control group; ^#P<0.05 and ^##P<0.01 vs. the OGD/R group; ⁺P<0.05 and ⁺⁺P<0.01 vs. the OGD/R + siPPAR-γ group; ⁻P<0.05 and ⁻⁻P<0.01 vs. the RS + OGD/R + siPPAR-γ group. OGD/R, oxygen-glucose deprivation/reperfusion; cyt c, cytochrome c; RS, rosuvastatin; ATR, atractyloside; si, small interfering RNA; PPAR-γ, peroxisome proliferator-activated receptor-γ; UCP2, mitochondrial uncoupling protein 2.