Table II.
Correlation between the expression of CTSS and patient clinicopathological characteristics.
| CTSS subgroupa | |||
|---|---|---|---|
| Variables | Low (%) | High (%) | P-valueb |
| No. of cases | 251 | 250 | |
| Age (years) | 0.140 | ||
| <45 | 106 (46.5) | 122 (53.5) | |
| ≥45 | 145 (53.1) | 128 (46.9) | |
| Sex | 0.244 | ||
| Male | 62 (45.9) | 73 (54.1) | |
| Female | 187 (51.8) | 174 (48.2) | |
| Maximum tumor size (cm) | 0.529 | ||
| <4 | 177 (49.6) | 180 (50.4) | |
| ≥4 | 64 (52.9) | 57 (47.1) | |
| Multifocality | 0.495 | ||
| Unifocal | 129 (48.7) | 136 (51.3) | |
| Multifocal | 117 (51.8) | 109 (48.2) | |
| ETE | 0.230 | ||
| No | 183 (55.1) | 149 (44.9) | |
| Yes | 59 (48.8) | 62 (51.2) | |
| T stage | 0.133 | ||
| T1-T2 | 162 (52.8) | 145 (47.2) | |
| T3-T4 | 89 (45.9) | 105 (54.1) | |
| LNM | <0.001d | ||
| N0 | 129 (57.1) | 97 (42.9) | |
| N1 | 87 (38.7) | 138 (61.3) | |
| TNM stage | 0.049c | ||
| I–II | 177 (53.0) | 157 (47.0) | |
| III–IV | 72 (43.6) | 93 (56.4) | |
| Histological type | <0.001d | ||
| Classical PTC | 144 (44.6) | 179 (55.4) | |
| Follicular PTC | 77 (77.8) | 22 (22.2) | |
| Tall-cell PTC | 8 (23.5) | 26 (76.5) | |
a
Median expression level was used as a cut-off to divide the 501 patients into low-CTSS group (n=251) and high-CTSS group (n=250)
b
Chi-square test; ETE, extrathyroidal extension; LNM, lymph node metastasis; TNM, tumor-node-metastasis
c
P<0.05.
d
P<0.001.