Table VI.
Biological process and pathway analysis of genes whose products are positively correlated with CCNF expression.
| Factor | P-value | Number of genes | Gene list |
|---|---|---|---|
| Biological process | |||
| Regulation of cell cycle | 1.88E-10 | 13 | CHEK2, FOXM1, CCNE1, CDKN1A, RB1, TSC2, RPS6KB1, CDK1, CHEK1, PCNA, EIF4EBP1, SRC, CCNB1 |
| Cell cycle phase transition | 1.94E-10 | 11 | CHEK2, FOXM1, CCNE1, CDKN1A, RB1, RPS6KB1, CDK1, CHEK1, PCNA, EIF4EBP1, CCNB1 |
| Cell cycle G1/S phase transition | 2.22E-10 | 9 | CHEK2, CCNE1, CDKN1A, RB1, RPS6KB1, CDK1, PCNA, EIF4EBP1, CCNB1 |
| Positive regulation of cell cycle | 1.82E-09 | 9 | CHEK2, CDKN1A, RB1, RPS6KB1, CDK1, PCNA, EIF4EBP1, SRC, CCNB1 |
| Regulation of DNA metabolic process | 2.32E-09 | 9 | CHEK2, FOXM1, CDKN1A, MSH6, PARP1, CDK1, CHEK1, PCNA, SRC |
| Cell cycle arrest | 4.10E-09 | 8 | CHEK2, FOXM1, CDKN1A, RB1, TSC2, CDK1, PCNA, CCNB1 |
| Negative regulation of mitotic cell cycle phase transition | 8.06E-09 | 7 | CHEK2, CDKN1A, RB1, CDK1, CHEK1, PCNA, CCNB1 |
| Negative regulation of G1/S transition of mitotic cell cycle | 2.07E-08 | 6 | CHEK2, CDKN1A, RB1, CDK1, PCNA, CCNB1 |
| DNA damage checkpoint | 1.70E-07 | 6 | CHEK2, CDKN1A, CDK1, CHEK1, PCNA, CCNB1 |
| Positive regulation of macromolecule biosynthetic process | 1.94E-07 | 12 | CHEK2, FOXM1, CCNE1, RB1, PARP1, TSC2, EEF2, RPS6KB1, CDK1, CHEK1, PCNA, SRC |
| DNA repair | 3.08E-07 | 8 | CHEK2, FOXM1, MSH6, PARP1, CDK1, CHEK1, PCNA, XRCC1 |
| Positive regulation of gene expression | 3.21E-07 | 12 | CHEK2, FOXM1, CCNE1, RB1, PARP1, TSC2, EEF2, RPS6KB1, CDK1, CHEK1, SRC, CCNB1 |
| Positive regulation of cell cycle arrest | 3.74E-07 | 5 | CHEK2, CDKN1A, CDK1, PCNA, CCNB1 |
| Positive regulation of cellular biosynthetic process | 3.74E-07 | 12 | CHEK2, FOXM1, CCNE1, RB1, PARP1, TSC2, EEF2, RPS6KB1, CDK1, CHEK1, PCNA, SRC |
| Pathway | |||
| Cell cycle | 1.06E-09 | 8 | CHEK2, CCNE1, CDKN1A, RB1, CDK1, CHEK1, PCNA, CCNB1 |
| p53 signaling pathway | 1.06E-09 | 7 | CHEK2, CCNE1, CDKN1A, TSC2, CDK1, CHEK1, CCNB1 |
| FOXM1 transcription factor network | 1.61E-09 | 6 | CHEK2, FOXM1, RB1, CDK1, CCNB1, XRCC1 |
| E2F mediated regulation of DNA replication | 9.24E-08 | 5 | CCNE1, RB1, CDK1, PCNA, CCNB1 |
| mTOR signaling pathway | 9.46E-07 | 5 | CCNE1, TSC2, EEF2, RPS6KB1, EIF4EBP1 |
| ATM signaling pathway | 4.84E-05 | 3 | CHEK2, CDKN1A, CHEK1 |
| DNA double-strand break repair | 5.32E-05 | 5 | CHEK2, PARP1, CHEK1, PCNA, XRCC1 |
| ErbB signaling pathway | 8.14E-05 | 4 | CDKN1A, RPS6KB1, EIF4EBP1, SRC |
| Endocrine resistance | 1.16E-04 | 4 | CDKN1A, RB1, RPS6KB1, SRC |
| HIF-1 signaling pathway | 1.39E-04 | 4 | CDKN1A, RPS6KB1, EIF4EBP1, TFRC |
| Base excision repair | 1.57E-04 | 3 | PARP1, PCNA, XRCC1 |
| AMPK signaling pathway | 2.39E-04 | 4 | TSC2, EEF2, RPS6KB1, EIF4EBP1 |
| PI3K-Akt signaling pathway | 7.78E-04 | 5 | CCNE1, CDKN1A, TSC2, RPS6KB1, EIF4EBP1 |
| Mismatch repair | 1.42E-03 | 2 | MSH6, PCNA |
CCNF, cyclin F. P-values were corrected for multiple comparisons using the false discovery rate (FDR) (Benjamini and Hochberg).