Table X.
Biological process and pathway analysis of genes whose products are positively correlated with RRM2 expression.
| Factor | P-value | Number of genes | Gene list |
|---|---|---|---|
| Biological process | |||
| Cell cycle phase transition | 1.99E-08 | 9 | CHEK2, FOXM1, CDKN1A, RB1, RPS6KB1, CHEK1, PCNA, EIF4EBP1, CCNB1 |
| Cell cycle G1/S phase transition | 9.08E-08 | 7 | CHEK2, CDKN1A, RB1, RPS6KB1, PCNA, EIF4EBP1, CCNB1 |
| Negative regulation of cell cycle phase transition | 1.97E-07 | 6 | CHEK2, CDKN1A, RB1, CHEK1, PCNA, CCNB1 |
| Cell cycle | 1.97E-07 | 11 | CHEK2, FOXM1, CDKN1A, RB1, MSH6, RPS6KA1, RPS6KB1, CHEK1, PCNA, EIF4EBP1, CCNB1 |
| Positive regulation of cell cycle | 2.96E-07 | 7 | CHEK2, CDKN1A, RB1, RPS6KB1, PCNA, EIF4EBP1, CCNB1 |
| Cell cycle process | 3.83E-07 | 10 | CHEK2, FOXM1, CDKN1A, RB1, MSH6, RPS6KB1, CHEK1, PCNA, EIF4EBP1, CCNB1 |
| Regulation of cell cycle | 5.63E-07 | 9 | CHEK2, FOXM1, CDKN1A, RB1, RPS6KB1, CHEK1, PCNA, EIF4EBP1, CCNB1 |
| Negative regulation of cell cycle G1/S phase transition | 5.94E-07 | 5 | CHEK2, CDKN1A, RB1, PCNA, CCNB1 |
| Regulation of cell cycle arrest | 7.05E-07 | 5 | CHEK2, FOXM1, CDKN1A, PCNA, CCNB1 |
| Signal transduction by p53 class mediator | 1.11E-06 | 6 | CHEK2, FOXM1, CDKN1A, CHEK1, PCNA, CCNB1 |
| Signal transduction in response to DNA damage | 1.11E-06 | 5 | CHEK2, FOXM1, CDKN1A, PCNA, CCNB1 |
| DNA integrity checkpoint | 3.58E-06 | 5 | CHEK2, CDKN1A, CHEK1, PCNA, CCNB1 |
| Regulation of cell proliferation | 1.36E-04 | 8 | FOXM1, CDKN1A, RB1, RAF1, RPS6KB1, CHEK1, CCNB1, TFRC |
| Regulation of cell growth | 2.26E-04 | 5 | FOXM1, CDKN1A, RB1, RPS6KA1, TFRC |
| Pathway | |||
| Cell cycle | 6.87E-07 | 6 | CHEK2, CDKN1A, RB1, CHEK1, PCNA, CCNB1 |
| Insulin signalling | 9.14E-06 | 4 | RAF1, RPS6KA1, RPS6KB1, EIF4EBP1 |
| FOXM1 transcription factor network | 9.14E-06 | 4 | CHEK2, FOXM1, RB1, CCNB1 |
| mTOR signaling pathway | 5.69E-05 | 4 | RAF1, RPS6KA1, RPS6KB1, EIF4EBP1 |
| p53 signaling pathway | 6.70E-05 | 4 | CHEK2, CDKN1A, CHEK1, CCNB1 |
| ATM signaling pathway | 9.01E-05 | 3 | CHEK2, CDKN1A, CHEK1 |
| ErbB signaling pathway | 1.04E-04 | 4 | CDKN1A, RAF1, RPS6KB1, EIF4EBP1 |
| HIF-1 signaling pathway | 1.53E-04 | 4 | CDKN1A, RPS6KB1, EIF4EBP1, TFRC |
| E2F mediated regulation of DNA replication | 2.21E-04 | 3 | RB1, PCNA, CCNB1 |
| G2/M DNA damage checkpoint | 2.21E-04 | 2 | CHEK1, CCNB1 |
| G1/S Transition | 2.34E-04 | 4 | CDKN1A, RB1, PCNA, CCNB1 |
| EGFR tyrosine kinase inhibitor resistance | 1.20E-03 | 3 | RAF1, RPS6KB1, EIF4EBP1 |
| RB tumor suppressor/checkpoint signaling in response to DNA damage | 1.25E-03 | 2 | RB1, CHEK1 |
| MAPKinase signaling pathway | 1.49E-03 | 3 | RAF1, RPS6KA1, RPS6KB1 |
RRM2, ribonucleotide reductase family member 2. P-values were corrected for multiple comparisons using the false discovery rate (FDR (Benjamini and Hochberg).