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. 2018 Apr 25;40(1):217–225. doi: 10.3892/or.2018.6399

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Schematic representation of the roles of FGF/FGFR/βKlotho signaling and AR signaling in epithelial-mesenchymal transition in prostate cancer. ERK phosphorylation was reported to induce the EMT process and our study revealed that βKlotho inhibited EMT of prostate cancer through inhibition of ERK phosphorylation. The βKlotho/ERK1/2/EMT axis is revealed in a red dotted line. AR, androgen receptor; EMT, epithelial-mesenchymal transition.