Table 3.
Association between MetS and EA compared with population controls, stratified by gastroesophageal reflux status
| No GERD | GERD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EA cases N= 2,339 |
Population controls N= 12,991 |
EA cases N= 828 |
Population controls N= 2,844 |
|||||||||
| Exposure | N | % | N | % | OR (95% CI)2 | P Value | N | % | N | % | OR (95% CI)2 | P Value |
| MetS1 | 614 | 26.3 | 2,959 | 22.8 | 1.19 (1.08, 1.32) | 0.001 | 256 | 30.9 | 841 | 29.6 | 1.07 (0.90, 1.27) | 0.455 |
| p-value of effect modification | P=0.231 | |||||||||||
| Metabolic conditions | ||||||||||||
| Obesity | 116 | 5 | 460 | 3.5 | 1.39 (1.13, 1.72) | 0.002 | 56 | 6.8 | 165 | 5.8 | 1.17 (0.85, 1.61) | 0.331 |
| Elevated fasting glucose | 734 | 31.4 | 3,687 | 28.4 | 1.14 (1.04, 1.26) | 0.006 | 294 | 35.5 | 967 | 34 | 1.07 (0.91, 1.26) | 0.426 |
| High blood pressure | 1,648 | 70.5 | 8,782 | 67.6 | 1.12 (1.02, 1.24) | 0.020 | 687 | 83 | 2,365 | 83.2 | 0.98 (0.79, 1.21) | 0.864 |
| Elevated triglycerides | 1,495 | 63.9 | 8,274 | 63.7 | 1.00 (0.91, 1.10) | 0.968 | 619 | 74.8 | 2,228 | 78.3 | 0.81 (0.67, 0.97) | 0.023 |
| Number of conditions | ||||||||||||
| 1+ | 1,899 | 81.2 | 10,470 | 80.6 | 1.02 (0.91, 1.14) | 0.749 | 780 | 94.2 | 2,681 | 94.3 | 0.98 (0.70, 1.38) | 0.902 |
| 2+ | 1,427 | 61 | 7,604 | 58.5 | 1.09 (1.00, 1.20) | 0.056 | 592 | 71.5 | 2,127 | 74.8 | 0.83 (0.70, 0.99) | 0.043 |
| 3+ | 613 | 26.2 | 2,925 | 22.5 | 1.21 (1.09, 1.34) | <0.001 | 256 | 30.9 | 835 | 29.4 | 1.08 (0.91, 1.28) | 0.382 |
| 4 | 54 | 2.3 | 204 | 1.6 | 1.44 (1.06, 1.95) | 0.020 | 28 | 3.4 | 82 | 2.9 | 1.19 (0.76, 1.85) | 0.448 |
Abbreviations: EA, esophageal adenocarcinoma; BE, Barrett’s esophagus; MetS, metabolic syndrome; OR, odds ratio; CI, confidence interval.
1
NCEP-ATP III definition
2
All models were adjusted for age, sex, race, registry, smoking