Figure 1.

Canagliflozin-Administration Accelerated Perfusion Recovery Following Unilateral Femoral Artery Ligation

Canagliflozin (n = 7) or vehicle (n = 8) were administered by oral gavage daily for 28 days. On day 7, unilateral femoral artery ligation and excision surgery was performed. The recovery of perfusion was measured every week for 3 weeks by laser Doppler perfusion imaging. (A and B) Canagliflozin-treated mice showed significantly increased perfusion ratios (white text) on day 28 compared with vehicle control mice. (C) Representative photomicrographs of CD31+ cells marking capillaries within ischemic limbs administered Canagliflozin or vehicle control mice. (D) Canagliflozin-treated mice showed increased capillary density in the ischemic muscle compared with vehicle-treated mice. Data are shown as mean ± SEM (*p < 0.05 by nonparametric Mann-Whitney U test).