Table 1.
Clinical and demographic characteristics of participants. A) Screening cohort for analysis of CRP as a primary screen, using TB culture as the reference standard; B) Triage cohort, persons with a positive symptom screen, using probable TB as the reference standard.
| A. | Total | No pulmonary TB | Pulmonary TB | p-value |
|---|---|---|---|---|
| Screening cohort, N(%) | 425 (100) | 383 (90) | 42 (10) | |
| Sex, N(%) | ||||
| Male | 177 (42) | 154 (40) | 23 (55) | |
| Female | 248 (58) | 229 (60) | 19 (45) | 0.069 |
| Age, Median (IQR) | 31.6 (26.6–39.3) | 31.3 (26.2–38.7) | 36.2 (31.6–41.6) | 0.001 |
| CD4 cells/mm3, median (IQR) | 306 (176–468) N=411 |
340 (189–485) N=371 |
129 (70–311) N=40 |
<0.001 |
| Prior TB, N (%) | 19 (4) | 17 (4) | 2 (4) | 0.92 |
| BMI, Median (IQR) | 24 (21–28) | 25 (21–30) | 24 (19–27) | 0.008 |
| TB symptoms, N(%) | ||||
| Current cough | 191 (55) | 159 (42) | 32 (76) | <0.001 |
| Fever | 129 (30) | 107 (28) | 22 (52) | 0.001 |
| Weight loss | 139 (33) | 118 (31) | 28 (67) | <0.001 |
| Night sweats | 146 (34) | 114 (30) | 25 (59) | <0.001 |
| No. symptoms, N(%) | ||||
| 0 | 146 (34) | 142 (37) | 4 (9) | |
| 1 | 100 (24) | 94 (25) | 6 (14) | |
| 2 | 79 (19) | 70 (18) | 9 (21) | |
| 3 | 53 (12) | 44 (11) | 9 (21) | |
| 4 | 47 (11) | 33 (8) | 14 (33) | <0.001 |
| CRP mg/L; median (IQR) | 4.1 (1.3–17.4) |
3.5 (1.2–11.8) |
42.3 (16.2–102.8) |
<0.001 |
| B. | Total | No TB | TB | p-value |
|---|---|---|---|---|
| Triage cohort, N (%) | 749 (100) | 671 (90) | 78 (10) | |
| Sex, N (%) | ||||
| Male | 341 (46) | 290 (43) | 51 (65) | |
| Female | 408 (54) | 381 (57) | 27 (35) | <0.001 |
| Age, Median (IQR) | 33.4 (27.0–39.5) | 33.1 (27.7–40.5) | 34.4 (30.2–40.9) | 0.11 |
| CD4 cells/mm3, median (IQR) | 268 (118–431) N=722 |
286 (141–449) N=650 |
98 (41–226) N=72 |
<0.001 |
| Prior TB, N (%) | 51 (6.8) | 45 (6.7) | 6 (7.7) | 0.74 |
| BMI, Median (IQR) | 23.3 (20.2–27.0) | 23.6 (20.5–27.1) | 20.5 (18.9–23.9) | <0.001 |
| TB symptoms, N(%) | ||||
| Current cough | 458 (61) | 389 (58) | 69 (89) | <0.001 |
| Fever | 386 (52) | 326 (49) | 60 (77) | <0.001 |
| Weight loss | 386 (52) | 325 (48) | 61 (78) | <0.001 |
| Night sweats | 334 (45) | 285 (42) | 49 (63) | 0.001 |
| No. symptoms, N(%) | ||||
| 0 | -- | -- | -- | |
| 1 | 292 (39) | 287 (43) | 5 (6) | |
| 2 | 212 (28) | 195 (29) | 17 (22) | |
| 3 | 132 (18) | 118 (16) | 24 (31) | |
| 4 | 113 (15) | 81 (12) | 32 (41) | <0.001 |
| CRP mg/L; median (IQR) | 6.9 (1.7–34.6) |
5.3 (1.5–24.4) |
83 (37.7–135.3) |
<0.001 |
IQR, interquartile range; BMI, body mass index; No., number; CRP, C-reactive protein.