Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The antimicrobial activity and selectivity of α/α-AA peptide hybrid shown in Scheme 2.
| MIC (μg/mL) | Hemolytic activity HC50 (μg/mL) | Selectivity (HC50/MIC of MRSA) | |||||
|---|---|---|---|---|---|---|---|
| Compound | Gram + | Gram − | |||||
| MRSA | MRSE | E. faecalis | E. coli | K. pneumonia | |||
| C16-K-RBB1 | 1.5 | 1.5 | 3 | 3 | 3 | 125 | 83 |
| C16-K-RBB2 | 1.5 | 1.5 | 3 | 3 | >25 | >250 | >167 |
| C16-K-RBB3 | 3–6 | 3–6 | 6–12 | 6–12 | >25 | >250 | >42 |
